Single-Molecule Studies of Chromosome Organization by SMC
نویسندگان
چکیده
منابع مشابه
Experimental Studies of Bacterial Chromosome Organization
Garmendia, E. 2017. A Unified Multitude. Experimental Studies of Bacterial Chromosome Organization. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1392. 66 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0140-2. Bacteria are many, old and varied; different bacterial species have been evolving for millions of years and show many disparate life-...
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Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain connected by a 49 nm coiled-coil "arm." The heads undergo ATP-dependent engagement and disengagement to drive SMC action on the chromosome. Here, we elucidate...
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DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms of many repair proteins have been examined separately in vitro, far less is known about the coordinated function of the whole repair machinery in vivo. Furthermore, single-cell studies indicate that DNA damage responses generate substantial variation in repair activities across cells. This revie...
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متن کاملSingle-molecule studies of the replisome.
Replication of DNA is carried out by the replisome, a multiprotein complex responsible for the unwinding of parental DNA and the synthesis of DNA on each of the two DNA strands. The impressive speed and processivity with which the replisome duplicates DNA are a result of a set of tightly regulated interactions between the replication proteins. The transient nature of these protein interactions ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.254